![Are we ready for AI to support clinical decisions?<br /><br />Lynne Chou O'Keefe of Define Ventures outlines the three waves of AI transforming healthcare: operational efficiency, clinical workflow, and clinical decision support.<br /><br />AI first tackled administrative friction. Now it is moving closer to the clinical core. The difference between guiding action and making a diagnosis matters.<br /><br /> Watch now, then listen to the full AI and the Future of Work episode.<br />👇 [#Podcast episode 374] 🎧 Listen here: https://open.spotify.com/episode/1pW138M3rpYN7lwAveoKbh?si=cef5d93e52bb4809](https://i.ytimg.com/vi/xpeE1TvvpRs/maxresdefault.jpg)
![Are we ready for AI to support clinical decisions?<br /><br />Lynne Chou O'Keefe of Define Ventures outlines the three waves of AI transforming healthcare: operational efficiency, clinical workflow, and clinical decision support.<br /><br />AI first tackled administrative friction. Now it is moving closer to the clinical core. The difference between guiding action and making a diagnosis matters.<br /><br /> Watch now, then listen to the full AI and the Future of Work episode.<br />👇 [#Podcast episode 374] 🎧 Listen here: https://open.spotify.com/episode/1pW138M3rpYN7lwAveoKbh?si=cef5d93e52bb4809](https://ainews.cafe/wp-content/plugins/youtube-feed-pro/img/placeholder.png)
AI Waves in Healthcare
Are we ready for AI to support clinical decisions?
Lynne Chou O'Keefe of Define Ventures outlines the three waves of AI transforming healthcare: operational efficiency, clinical workflow, and clinical decision support.
AI first tackled administrative friction. Now it is moving closer to the clinical core. The difference between guiding action and making a diagnosis matters.
Watch now, then listen to the full AI and the Future of Work episode.
👇 [#Podcast episode 374] 🎧 Listen here: https://open.spotify.com/episode/1pW138M3rpYN7lwAveoKbh?si=cef5d93e52bb4809
375: How AI Is Changing Healthtech Investing, According to Define Ventures’ Lynne Chou O’Keefe
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Lynne Chou O’Keefe is the Founder and Managing Partner of Define Ventures, one of the largest early-stage health tech investment firms, with $800 million in assets under management.
With deep experience across digital health, venture capital, and frontline healthcare systems, Lynne brings a clear-eyed view of why the industry is changing now and where AI can make a meaningful difference.
She is widely recognized for her work backing companies that rethink access, outcomes, and patient experience, and is a trusted voice on how technology, ethics, and human judgment must come together to move healthcare forward.
In this conversation, we discuss:
• Why healthcare still runs on fragmented systems and what that means for where AI can truly move the needle.
• How the shift from fee-for-service to value-based care changes incentives and pushes the system toward prevention over volume.
• Why patients now expect healthcare to work like transportation or food delivery, and how that expectation reshapes care delivery.
• The three phases of AI in healthcare, from administrative efficiency to clinical workflow support and, eventually, clinical decision-making.
• Where the ethical boundary sits today between AI-assisted care and AI-led decisions, especially when access to care is limited.
• Why the future of healthcare is hybrid by design, with AI augmenting clinicians rather than replacing human judgment.
Resources:
• Subscribe to the AI & The Future of Work Newsletter (https://aiandwork.beehiiv.com/subscribe)
• Connect with Lynn on LinkedIn (https://www.linkedin.com/in/lynne-chou-o-keefe-5617a/)
• AI fun fact article (https://www.vaticannews.va/en/vatican-city/news/2025-11/medical-professionals-rome-ai-healthcare-conference-kloiber.html)
• On how AI is fixing the biggest problem faced by doctors. (https://www.buzzsprout.com/520474/episodes/12739445)
Why AI Disruption Feels Different This Time
Every year, Dave Kellogg publishes one of the most talked-about prediction posts in tech.
In this clip from AI and the Future of Work, he reflects on why today’s AI conversations feel more personal and why navigating what comes next requires trust.
This moment comes from our annual tradition of revisiting predictions, challenging assumptions, and looking ahead.
🎧 Watch the full episode of AI and the Future of Work to hear the complete conversation.
374: Dave Kellogg Unpacks the 2026 Predictions on SaaS, AI, and Trust
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Dave Kellogg is a leading voice in enterprise software, SaaS metrics and go-to-market strategy. A four-time guest on AI and the Future of Work, Dave brings decades of hands-on experience inside SaaS companies to challenge how leaders think about growth, metrics, and execution. He is an Executive-in-Residence at Balderton Capital and the author of Kellblog. His perspective is shaped by years spent leading and advising software businesses from early stages through scale.
In this conversation, we discuss:
• Why Dave argues that we are increasingly working for the algorithm, not the other way around, and how that shift shows up in SEO, productivity, and workplace behavior.
• Why SaaS is not dying but is under real pressure, and how claims that companies can easily replace systems like Salesforce or Workday misunderstand how enterprise software actually works.
• How AI changes jobs by pushing work up the value chain rather than simply eliminating roles, and why history suggests societies adapt faster than we expect.
• Why trust becomes more valuable as AI floods the world with low-quality content, and how brands, creators, and leaders must earn credibility in an era of front-run information.
• What the move from the Rule of 40 to the Rule of 60 signals about today’s market, and why many mid-scale SaaS companies now face uncomfortable strategic choices.
• How venture capital is becoming more financialized, what that means for founders, and why AI may accelerate the shift toward larger funds, bigger bets, and fewer safety nets.
Episode Chapters
00:00 Why Dave Kellogg’s Annual SaaS Predictions Matter More Every Year
03:53 Working for the Algorithm, Not the Other Way Around
06:10 “Death of SaaS”: Why Enterprise Software Isn’t Going Away
08:56 Why Enterprise Software Is Built to Last
11:51 AI and Jobs: Why Work Disappears Differently Than We Expect
16:31 The New Jobs AI Creates and Why Humans Stay Essential at Work
19:22 Why Trust Becomes the Most Valuable Currency in an AI-Driven World
24:23 Why AI Forces Us to Rethink Trust, Media, and Credibility
27:57 Why the Rule of 60 Is Replacing the Rule of 40 for Startups in 2026
33:44 How Venture Capital Is Becoming a Financial Services Business
41:47 Why Silicon Valley’s New Willingness to Take Political Positions Surprised Many Founders
45:57 What the Grateful Dead Can Teach Us About Business, Creativity, and Legacy
Resources:
• Subscribe to the AI & The Future of Work Newsletter (https://aiandwork.beehiiv.com/subscribe)
• Connect with Dave Kellogg on LinkedIn (https://www.linkedin.com/in/kelloggdave/)
• Kellblog Predictions for 2026 (https://kellblog.com/2026/01/22/kellblog-predictions-for-2026/)
• AI fun fact article (https://venturebeat.com/ai/4-bold-ai-predictions-for-2025/)
• On How AI is Making Networks Smart (https://podcasts.apple.com/us/podcast/dr-jp-vasseur-cisco-fellow-prolific-author-and-holder/id1476885647?i=1000604981093)
• Previous episodes in AI & The Future of Work featuring Dave:
• [2025] 324: 2025 predictions with Dave Kellogg: The Future of AI, SaaS, and Business (https://www.buzzsprout.com/520474/episodes/16665133)
• [2024] Dave Kellogg, SaaS whisperer and EIR at Balderton Capital, predicts the future of AI, Silicon Valley, and venture capital (https://www.buzzsprout.com/520474/episodes/14391285)
• [2023] Special episode: Dave Kellogg, serial CEO, investor, and SaaS pioneer, shares his (provocative) tech predictions for 2023 (https://www.buzzsprout.com/520474/episodes/12052967)
Why Career Paths Are Obsolete and Learning Paths Matter More Than Ever
The world of work is changing faster than at any time in living memory, and the traditional advice of “get the right degree, get the right job” no longer applies.
In this clip from AI and the Future of Work, Lynn Thoman explains why the people who thrive in the age of AI aren’t those with fixed career paths, but those who stay curious, adaptable, and committed to continuous learning.
This conversation explores:
• Why learning paths matter more than career paths
• How curiosity and adaptability become career superpowers
• Why your first job is a launch pad, not a destination
• What employers really look for in a rapidly changing economy
🎧 Watch the full episode of AI and the Future of Work
AI in the Public Sector for Better Service Experiences: Lessons from Leaders
State and local government, as well as higher education entities, have many of the same employee service use cases as the private sector. But they also have some unique compliance requirements and considerations.
In this session, public sector leaders share their experiences and best practices for implementing AI.
373: From Credentials to Curiosity: Why Learning Paths Matter More Than Career Paths, with Columb...
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Lynn Thoman is a professor at Columbia University’s School of International and Public Affairs and the founder of 3 Takeaways, a top 1% global podcast known for distilling big ideas from influential leaders shaping policy, business, and society.
Drawing on experience across corporate strategy, public sector advisory work, and board service at institutions such as the Brookings Institution and Harvard’s Kennedy School of Government, Lynn brings a cross-sector lens to how AI is reshaping decision-making, learning, and human potential.
In this conversation, we discuss:
• Why AI is best understood as an amplifier of human capability, especially in leadership, where judgment and choices matter more than technology.
• How the real upside of AI is giving people more space for imagination, empathy, and meaningful human connection.
• How to prepare students and professionals for an AI-shaped job market by prioritizing learning paths, adaptability, and relationships over fixed career tracks.
• Why the biggest risks of AI come from small, hard-to-detect changes in data or models that can create serious downstream harm.
• How AI is pushing education, work, and leadership back toward core human skills like judgment, curiosity, and imagination.
• Where cautious optimism comes from, including AI’s potential to expand access to knowledge, healthcare, and opportunity when used with care.
Resources:
• Subscribe to the AI & The Future of Work Newsletter (https://aiandwork.beehiiv.com/subscribe)
• Connect with Lynn on LinkedIn (https://www.linkedin.com/in/lynn-thoman/)
• AI fun fact article (https://www.pewresearch.org/short-reads/2025/11/06/republicans-democrats-now-equally-concerned-about-ai-in-daily-life-but-views-on-regulation-differ/)
• On How genAI studios launch AI-first companies (https://www.buzzsprout.com/520474/episodes/13833044-paul-allen-founder-of-ancestry-com-and-soar-discusses-how-genai-studios-launch-ai-first-companies)
Other podcast episodes mentioned on the show:
• On reinventing the academic curriculum for MBAs with Dave Marchick, Dean of the Kogod School of Business (https://www.buzzsprout.com/520474/episodes/17119724)
• From 3 Takeaways:
• The Genetic Revolution Has Begun - George Church on What Comes Next (https://www.3takeaways.com/episodes/genetics-synthetic-biology-george-church)
• The Transforming Power of Hospitality in Business: Setting the Table with Union Square Hospitality Group Founder & CEO Danny Meyer (https://www.3takeaways.com/episodes/union-square-danny-meyer)
Why CRM Tracks Customers but Revenue AI Runs Sales | Amit Bendov CEO of Gong
CRM tracks customers.
Revenue AI runs the sale.
Amit Bendov, co-founder and CEO of Gong, defines Revenue AI as a new category built to do the work, not just record it.
In this clip, he explains how AI moves sales from documentation to execution by forecasting outcomes, guiding sellers, and driving revenue decisions in real time.
👇 [#Podcast episode 372]
Watch now, then listen to the full AI and the Future of Work episode.
🎧 Link in the comments.
#AI #FutureOfWork #Sales #RevenueAI #Gong #Leadership #PeopleReign #Podcast #TeamHuman
AI and Education: How Artificial Intelligence Is Transforming Learning (International Day of Educ...
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Every January 24, the world celebrates the International Day of Education, a reminder that learning remains one of the most powerful drivers of opportunity, mobility, and social progress.
In this special compilation episode of AI and the Future of Work, we revisit conversations with education leaders, university deans, and workforce innovators exploring how AI is transforming learning, access, credentials, and lifelong education.
From academic integrity and digital classrooms to reskilling and future-ready education models, this episode highlights one essential truth: technology can accelerate learning, but education must remain human-centered.
Featuring insights from:
• Chris Caren (CEO, Turnitin) - Listen to the full conversation here: https://aiandthefutureofwork.buzzsprout.com/520474/episodes/15780222
• Marni Baker Stein (Chief Content Officer, Coursera) - Listen to the full conversation here: https://aiandthefutureofwork.buzzsprout.com/520474/episodes/17359747
• Dave Treat (Chief Technology Officer, Pearson) - Listen to the full conversation here: https://aiandthefutureofwork.buzzsprout.com/520474/episodes/17557154
• Dave Marchick (Dean, Kogod School of Business, American University) - Listen to the full conversation here: https://aiandthefutureofwork.buzzsprout.com/520474/episodes/17119724
• Gary Bolles (Chair for the Future of Work, Singularity University) - Listen to the full conversation here: https://aiandthefutureofwork.buzzsprout.com/520474/episodes/9236086
What You’ll Learn:
• How AI is reshaping education and digital learning models
• Why academic integrity matters more than ever in the age of generative AI
• How universities and platforms expand access to global education
• Why lifelong learning and reskilling are becoming essential career skills
• How educators prepare students for future work and leadership
• Which human skills remain critical in an AI-driven economy
Inspired by something you heard?
Share this episode with someone passionate about education and the future of learning. And don’t forget to subscribe for more conversations with the leaders shaping the future of work.
Other special episodes:
• Lessons from Four Unicorn CEOs Disrupting Massive Markets with AI (Special Episode) (https://www.buzzsprout.com/520474/episodes/17547421)
• Artificial General Intelligence: Can Machines Really Think Like Us? (Special Episode) (https://www.buzzsprout.com/520474/episodes/18046011)
• Ethical AI in Hiring: How to Stay Compliant While Building a Fairer Future of Work (HR Day Special Episode) (https://www.buzzsprout.com/520474/episodes/17199568)
• AI and the Law: How AI Will Change Legal Careers (Special Episode) (https://www.buzzsprout.com/520474/episodes/13014260)
• AI and Safety: How Responsible Tech Leaders Build Trustworthy Systems (National Safety Month Special) (https://www.buzzsprout.com/520474/episodes/17366515)
• Lessons from Leaders: How AI Is Redefining Work and the Human Experience (Labor Day Special Episode) (https://www.buzzsprout.com/520474/episodes/17862976)
• 365: What We’ve Learned from 364 Expert Conversations (Special Episode) (https://www.buzzsprout.com/520474/episodes/18286628)
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AI Waves in Healthcare