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The ambiguity in medical imaging can present major challenges for clinicians who are trying to identify disease. For instance, in a chest X-ray, pleural effusion, an abnormal buildup of fluid in the lungs, can look very much like pulmonary infiltrates, which are accumulations of pus or blood.
An artificial intelligence model could assist the clinician in X-ray analysis by helping to identify subtle details and boosting the efficiency of the diagnosis process. But because so many possible conditions could be present in one image, the clinician would likely want to consider a set of possibilities, rather than only having one AI prediction to evaluate.
One promising way to produce a set of possibilities, called conformal classification, is convenient because it can be readily implemented on top of an existing machine-learning model. However, it can produce sets that are impractically large.
MIT researchers have now developed a simple and effective improvement that can reduce the size of prediction sets by up to 30 percent while also making predictions more reliable.

